The Glutamine Transporter Slc38a1 Regulates GABAergic Neurotransmission and Synaptic Plasticity

Cerebral cortex (New York, N.Y. : 1991)

GABA signaling sustains fundamental brain functions, from nervous system development to the synchronization of population activity and synaptic plasticity. Despite these pivotal features, molecular determinants underscoring the rapid and cell-autonomous replenishment of the vesicular neurotransmitter GABA and its impact on synaptic plasticity remain elusive. Here, we show that genetic disruption of the glutamine transporter Slc38a1 in mice hampers GABA synthesis, modifies synaptic vesicle…

Released at: 21.07.2020, written by webmaster_popp