System A transporter SAT2 mediates replenishment of dendritic glutamate pools controlling retrograde signaling by glutamate

Cerebral cortex (New York, N.Y. : 1991)

Glutamate mediates several modes of neurotransmission in the central nervous system including recently discovered retrograde signaling from neuronal dendrites. We have previously identified the system N transporter SN1 as being responsible for glutamine efflux from astroglia and proposed a system A transporter (SAT) in subsequent transport of glutamine into neurons for neurotransmitter regeneration. Here, we demonstrate that SAT2 expression is primarily confined to glutamatergic neurons in many…

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