Orthopedic surgery modulates neuropeptides and BDNF expression at the spinal and hippocampal levels

Proceedings of the National Academy of Sciences of the United States of America

Pain is a critical component hindering recovery and regaining of function after surgery, particularly in the elderly. Understanding the role of pain signaling after surgery may lead to novel interventions for common complications such as delirium and postoperative cognitive dysfunction. Using a model of tibial fracture with intramedullary pinning in male mice, associated with cognitive deficits, we characterized the effects on the primary somatosensory system. Here we show that tibial fracture…

Released at: 16.09.2020, written by webmaster_popp