Hypothalamic CNTF volume transmission shapes cortical noradrenergic excitability upon acute stress

The EMBO journal

Stress-induced cortical alertness is maintained by a heightened excitability of noradrenergic neurons innervating, notably, the prefrontal cortex. However, neither the signaling axis linking hypothalamic activation to delayed and lasting noradrenergic excitability nor the molecular cascade gating noradrenaline synthesis is defined. Here, we show that hypothalamic corticotropin-releasing hormone-releasing neurons innervate ependymal cells of the 3^(rd) ventricle to induce ciliary neurotrophic…

Released at: 16.09.2020, written by webmaster_popp