Hypothalamic cell diversity: non-neuronal codes for long-distance volume transmission by neuropeptides

Current opinion in neurobiology

Volume transmission is a mode of intercellular communication using cerebral liquor to deliver signal molecules over long distances and allow their action for extended periods. For hypothalamic neuropeptides, nerve endings amongst ependymal cells are seen as a site of release into the cerebrospinal fluid. Recent single-cell RNA-seq data identify tanycytes and ventricular ependyma as alternative sources by being unexpectedly rich in neuroactive substances. This notion, coupled with circuit…

Released at: 29.07.2020, written by webmaster_popp