Galantamine-induced behavioral recovery after sublethal excitotoxic lesions to the rat medial septum

Behavioural brain research

Clinical trials show beneficial effects of acetylcholinesterase (AChE) inhibitors, including galantamine, on cognitive functions in patients with mild to moderate Alzheimer’s disease. Galantamine shows a dual action profile by also acting as an allosteric modulator of nicotinic acetylcholine receptors. Nevertheless, its in vivo mechanism of action is only partly understood. Here, we first established a novel lesion model provoking significant functional impairment of the septo-hippocampal…

Released at: 23.09.2020, written by webmaster_popp