GABAergic terminals are a source of galanin to modulate cholinergic neuron development in the neonatal forebrain

Cerebral cortex (New York, N.Y. : 1991)

The distribution and (patho-)physiological role of neuropeptides in the adult and aging brain have been extensively studied. Galanin is an inhibitory neuropeptide that can coexist with γ-aminobutyric acid (GABA) in the adult forebrain. However, galanin’s expression sites, mode of signaling, impact on neuronal morphology, and colocalization with amino acid neurotransmitters during brain development are less well understood. Here, we show that galaninergic innervation of cholinergic projection…

Released at: 22.09.2020, written by webmaster_popp