Fetal endocannabinoids orchestrate the organization of pancreatic islet microarchitecture

Proceedings of the National Academy of Sciences of the United States of America

Endocannabinoids are implicated in the control of glucose utilization and energy homeostasis by orchestrating pancreatic hormone release. Moreover, in some cell niches, endocannabinoids regulate cell proliferation, fate determination, and migration. Nevertheless, endocannabinoid contributions to the development of the endocrine pancreas remain unknown. Here, we show that α cells produce the endocannabinoid 2-arachidonoylglycerol (2-AG) in mouse fetuses and human pancreatic islets, which primes…

Released at: 22.09.2020, written by webmaster_popp