Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning

Proceedings of the National Academy of Sciences of the United States of America

Endocannabinoids (eCBs) have recently been identified as axon guidance cues shaping the connectivity of local GABAergic interneurons in the developing cerebrum. However, eCB functions during pyramidal cell specification and establishment of long-range axonal connections are unknown. Here, we show that eCB signaling is operational in subcortical proliferative zones from embryonic day 12 in the mouse telencephalon and controls the proliferation of pyramidal cell progenitors and radial migration of…

Released at: 23.09.2020, written by webmaster_popp