Diversity matters: combinatorial information coding by GABAA receptor subunits during spatial learning and its allosteric modulation

Cellular signalling

In the hippocampus, GABA inhibition tunes network oscillations and shapes synchronous activity during spatial learning and memory coding. Once released from the presynapse, GABA primarily binds to ionotropic GABA(A) receptors (GABA(A)Rs), which are heteropentamers combinatorially assembled from nineteen known subunits to induce Cl^(-) currents postsynaptically. Dissecting GABA(A)R subtype specificities in neurobiology is daunting because of differences in their developmental dynamics, regional…

Released at: 16.09.2020, written by webmaster_popp