Diacylglycerol lipase α manipulation reveals developmental roles for intercellular endocannabinoid signaling

Scientific reports

Endocannabinoids are small signaling lipids, with 2-arachidonoylglycerol (2-AG) implicated in modulating axonal growth and synaptic plasticity. The concept of short-range extracellular signaling by endocannabinoids is supported by the lack of trans-synaptic 2-AG signaling in mice lacking sn-1-diacylglycerol lipases (DAGLs), synthesizing 2-AG. Nevertheless, how far endocannabinoids can spread extracellularly to evoke physiological responses at CB₁ cannabinoid receptors (CB₁Rs) remains poorly…

Released at: 22.09.2020, written by webmaster_popp