Cracking down on inhibition: selective removal of GABAergic interneurons from hippocampal networks

The Journal of neuroscience : the official journal of the Society for Neuroscience

Inhibitory (GABAergic) interneurons entrain assemblies of excitatory principal neurons to orchestrate information processing in the hippocampus. Disrupting the dynamic recruitment as well as the temporally precise activity of interneurons in hippocampal circuitries can manifest in epileptiform seizures, and impact specific behavioral traits. Despite the importance of GABAergic interneurons during information encoding in the brain, experimental tools to selectively manipulate GABAergic…

Released at: 23.09.2020, written by webmaster_popp