Chronic aluminum treatment results in aluminum deposits and affects Ml muscarinic receptors in rat brain

Neurobiology (Budapest, Hungary)

The effects of chronic aluminum (Al) administration on the deposition of the metal and on the receptor binding characteristics of the Ml muscarinic acetylcholine receptors (MlAChR) were studied in selected rat brain areas. Animals were injected intraperitoneally with an AlCl3 solution of 1.0 mg/ml/100 g of body weight for 5 weeks, 5 days a week. Al accumulation was detected by solochrome azurine histochemistry in the brain, where the metal could be visualized in capillaries, endothelial cells…

Released at: 05.08.2020, written by webmaster_popp