Autoantibodies in autoimmune polyglandular syndrome type I patients react with major brain neurotransmitter systems
The Journal of comparative neurology
The Journal of comparative neurology
Patients with autoimmune polyglandular syndrome type I (APS1) often display high titers of autoantibodies (autoAbs) directed against aromatic L-amino acid decarboxylase (AADC), tyrosine hydroxylase (TH), tryptophan hydroxylase (TPH), and glutamic acid decarboxylase (GAD). Neurological symptoms, including stiff-man syndrome and cerebellar ataxia, can occur in subjects with high levels of GAD autoAbs, particularly when patient sera can immunohistochemically stain gamma-aminobutyric acid (GABA)…
Released at: 23.09.2020, written by webmaster_popp
