Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy

The Journal of neuroscience : the official journal of the Society for Neuroscience

Alzheimer’s disease is associated with an increased risk of unprovoked seizures. However, the underlying mechanisms of seizure induction remain elusive. Here, we performed video-EEG recordings in mice carrying mutant human APPswe and PS1dE9 genes (APdE9 mice) and their wild-type littermates to determine the prevalence of unprovoked seizures. In two recording episodes at the onset of amyloid beta (Abeta) pathogenesis (3 and 4.5 months of age), at least one unprovoked seizure was detected in 65%…

Released at: 23.09.2020, written by webmaster_popp