A TRPV1-to-secretagogin regulatory axis controls pancreatic β-cell survival by modulating protein turnover

The EMBO journal

Ca^(2+)-sensor proteins are generally implicated in insulin release through SNARE interactions. Here, secretagogin, whose expression in human pancreatic islets correlates with their insulin content and the incidence of type 2 diabetes, is shown to orchestrate an unexpectedly distinct mechanism. Single-cell RNA-seq reveals retained expression of the TRP family members in β-cells from diabetic donors. Amongst these, pharmacological probing identifies Ca^(2+)-permeable transient receptor potential…

Released at: 16.09.2020, written by webmaster_popp