Mechanisms of beta-amyloid neurotoxicity: perspectives of pharmacotherapy
Reviews in the neurosciences
Reviews in the neurosciences
One of the characteristic neuropathological hallmarks of Alzheimer’s disease (AD) is the extracellular accumulation of beta-amyloid peptides (Abeta) in neuritic plaques. Experimental data indicate that different molecular forms of Abeta affect a wide array of neuronal and glial functions and thereby may lead to neuronal death in the nervous system. Whereas the fatal outcome of Abeta overproduction in transgenic cell lines, and of exogenous Abeta administration in numerous neurotoxicity models,…
Released at: 22.09.2020, written by webmaster_popp
